Efficacy and safety of peginterferon-α2b for treatment of myeloproliterative neoplasms / 南方医科大学学报

OBJECTIVE@#To evaluate the clinical efficacy and adverse reactions of peginterferon-α2b for treatment of chronic myeloproliferative neoplasms (MPN).@*METHODS@#We retrospectively analyzed the data of 107 patients with MPN, including 95 with essential thrombocythemia (ET) and 12 with polycythemia vera (PV), who all received peginterferon-α2b treatment for at least 12 months. The clnical and follow-up data of the patients were analyzed to evaluate the efficacy and adverse reactions of the treatment.@*RESULTS@#After receiving peginterferon- α2b treatment, both ET and PV patients achieved high hematological remission rates, and the total remission rates did not differ significantly between the two groups (86% vs 78%, P>0.05). In the overall patients, the spleen index decreased by 13.5% (95%CI: 8.5%-18.5%) after the treatment. The patients with hematological remission showed a significantly greater reduction of the total symptom score than those without hematological remission (P < 0.01). The median percentage of JAK2V617F allele load of PV patients decreased from 67.23% (49.6%-84.86%) at baseline to 19.7% (0.57%-74.6%) after the treatment, and that of JAK2V617F-positive ET patients decreased from 48.97% (0.45%-74.24%) at baseline to 22.1% (0.33%-65.42%) after the treatment. Mild adverse reactions (grade 1-2) were observed in both ET and PV groups without significant differences between them. The overall incidence of thrombotic events during the treatment was 2.8% in these patients, and no serious adverse reactions were observed.@*CONCLUSION@#For patients with chronic myelodysplasia, peginterferon-α2b treatment can achieve a high peripheral blood cell remission rate and maintain a long-term stable state with good effect in relieving symptoms such as splenomegaly. Peginterferon- α2b treatment caused only mild adverse reactions, which can be tolerated by most of the patients.

Comparative study on growth retardation prevalence in students aged 7-18 years from 26 minority ethnic groups in China / 中华流行病学杂志

Objective@#To compare the prevalence of growth retardation in students aged 7-18 years from 26 minority ethnic groups in China and provides reference evidence to promote the growth and improve the health status of students in minority ethnic groups.@*Methods@#The body height data of students aged 7-18 years in 26 minority ethnic groups in 2014 Chinese National Surveys on Students’ Constitution and Health were used for the analysis and comparison. Growth retardation was defined according to the school-aged child and adolescent malnutrition screening standard (WS/T 456-2014).@*Results@#In 2014, the average body heights of school boys and school girls aged 18 years in 26 ethnic minority groups were (168.3±6.8) cm and (156.2±5.9) cm respectively. The overall growth retardation prevalence rate of school boys and school girls in 26 ethnic groups were 5.4% and 5.1%, respectively. The growth retardation prevalence rate was highest in students of Shui ethnic group (24.5% for boys and 23.0% for girls), and lowest in students of Hui ethnic group (0.1% for boys and 0.3% for girls). The growth retardation prevalence rates in 9 ethnic minority groups were higher than the average level, in these 9 ethnic groups, the differences in prevalence rates of boys of Buyi ethnic group, girls of Lisu ethnic group and girls of Hani ethnic group had no significance among four age groups. Growth retardation in students of Sala ethnic group was mainly observed in age group 7-9 years, but in others ethnic group, for example, Wa ethnic, it was mainly observed in older age group. The students in minority ethnic groups in southwestern China had the highest growth retardation prevalence rate (8.1%), significantly higher than that in northern China (0.8%) (OR=10.6, 95%CI: 7.8-14.4). The overall growth retardation prevalence rate between 7 and 17 years old was negatively correlated with the body height of 18 years old (boys: r=-0.811, P<0.001; girls: r=-0.715, P<0.001).@*Conclusions@#In 2014, the differences in body height among students aged 18 years in 26 minority ethnic groups in China were significant. In general, the first five minority ethnic groups with high detection rate of growth retardation in boys were Shui, Wa, Buyi, Yao and Yi, and the five minority ethnic groups with high detection rate of growth retardation in girls were Shui, Yao, Buyi, Wa and Miao. The detection rate of growth retardation was highest in students of minority ethnic groups in southwestern China. Nutritional interventions and healthy education should be carried out in minority ethnic groups and areas with high growth retardation prevalence rate to promote the growth of the students.

The Influence of Curve Running on Patellofemoral Joint Stress / 医用生物力学

Objective To explore the changes in patellofemoral joint stress of lower limbs during curve running at a slower running speed, so as to analyze the possibility of increasing patellofemoral pain due to long curve running. Methods Newtest portable speed measurement system, Motion infrared high speed motion capture system, Kistler three-dimensional force plate were used to collect the kinematic parameters and ground reaction force from a total of 13 male college students without sports specialty at straight track and curve track (with inner diameter of 36 m) at the speed of (4.0±0.2) m/s. Results Compared with linear running, the patellofemoral joint stress at lateral side of the leg significantly increased during curve running. There were no significant differences in knee flexion angles and knee extensor moments when patellofemoral joint stress increased during curve running. Conclusions Long curve running is a contributing factor with respect to the development of patellofemoral pain in lateral leg and aggravating patellofemoral pain. It is suggested that running enthusiasts and patients with patellofemoral pain should avoid repeating long curve running.

Analysis of characteristics and influencing factors of fine particulate matters and submicron particulate matters in printing shop / 中华预防医学杂志

Objective@#To analyze the physical characteristics of fine particulate matters (PM2.5) and submicron particulate matters (PM1), and investigate the factors influencing the emission peak of printer particles.@*Methods@#A 12-hour particle concentration monitoring for PM2.5 and PM1 was conducted in a printing shop on January 5th, 2018. PM2.5 in the air was analyzed after the monitoring process to figure out morphological characteristics and element composition of printer particles. Besides, experiments were carried out in an enclosed space to detect the number concentration peaks of PM1 during every printing process. Influencing factors investigated in this study were printer types, toner coverages and interval time between different printing processes.@*Results@#The 12-hour particles concentration monitoring showed that the number concentration of PM1 and the mass concentration of PM2.5 were 7.510×104 pt/cm3 and 96.85 μg/m3. The diameter of most PM2.5 was less than 100 nm, with a fractal dimension of 2.591. Most PM2.5 appeared as regular spheres with typical agglomeration phenomenon, while some were in rhabditiform or irregular shapes. Element analysis showed that PM2.5 was mainly composed of C, O, Si, Ca, with less metallic element. The PM1 emission peak values of three printers were 3.60×104, 3.43×104, 0.31×104 pt/cm3, respectively and the difference was not statistically significant (χ2=5.42, P>0.05). When the page coverage rate was 0%, 2.5%, 5%, 10%, 20% and 50%, the PM1 emission peak value of printer A was 6.74×104, 4.62×104, 3.82×104, 2.82×104, 1.00×104 and 1.08×104 pt/cm3, and the difference was also not statistically significant (χ2=7.01, P>0.05). The natural logarithm of PM1 emission peak value in printing work was associated with the resting time before printing and the change value of heating roller temperature (r value was 0.83 and 0.89, respectively, all P values<0.05).@*Conclusion@#PM2.5 and PM1 in the printing shop stayed at a high level. Particles appeared as various shapes and element compositions were complex. The temperature change of heating roller was one of most important factors that lead to the increased number concentration peak of PM1.

Analysis on the urban-rural disparity of childhood stunting and its association with economic growth among Chinese Han students aged 7-18 years old / 中华预防医学杂志

Objective@#To analyze the urban-rural disparity of childhood stunting and its association with subnational economic growth among Chinese Han students aged 7-18 years.@*Methods@#We used the data from 2014 Chinese National Survey on Students′ Constitution and Health. 213 940 Chinese Han students aged 7-18 years with complete height records were included in this study. Stunting was defined according to the Screening Criteria of Malnutrition for School-age Children and Adolescents(2014 version, in Chinese). We divided students into two groups (economically developed and underdeveloped areas) according to the provincial GDP per capita. Spearman correlation coefficient was used to explore the association between the difference of urban-rural stunting prevalence and the provincial GDP per capita. Logistic regression models were established to assess the risk of stunting in rural children compared with urban children.@*Results@#Among 213 940 students, 107 033 (50.0%) were from urban areas. The average height of 7-18 years old and 18 years old [(152.9±15.7) and (166.1±8.7) cm] of urban students were both higher than those of rural students [(150.7±16.0) and (165.1±8.6) cm] (P<0.001). The stunting prevalence of Chinese urban students (0.4%) was statistically significant lower than that of rural students (1.1%) (P<0.001), which was consistent in all age groups (P<0.05). The urban-rural disparity was found in 60% (18/30) of Chinese provinces. The difference of urban-rural stunting prevalence was negatively associated with provincial GDP per capita (r=-0.62, P<0.001). In economically underdeveloped areas, the risk of stunting for rural students aged 7-9 years was 4.69 (95%CI: 2.93-7.52) times that for urban children, while for students aged 10-18 years, the odds ratio was 2.44 (95%CI: 2.02-2.96). In economically developed areas, the risk of stunting for rural students aged 7-9 years was 5.43 (95%CI: 3.67-8.03) times that for urban children, while for students aged 10-18 years, the odds ratio was 2.15 (95%CI: 1.85-2.49).@*Conclusions@#The urban-rural disparity of childhood stunting existed in most places in China. The difference of growth retardation between urban and rural areas was related to regional economic development.

The change in mortality and major causes of death among Chinese adolescents from 1990 to 2016 / 中华预防医学杂志

Objective@#To analyze the change in mortality and major causes of death among Chinese adolescents aged 10-19 years from 1990 to 2016.@*Methods@#Data of death for Chinese adolescents aged 10-19 years were extracted from the Global Burden of Disease Study 2016 (GBD 2016). The data was used to describe the change in mortality of Chinese adolescents from 1990 to 2016.Top 15 causes of death were compared between 1990 and 2016.@*Results@#From 1990 to 2016, the all-cause mortality of Chinese adolescents aged 10-19 years old dropped from 102.5/100 000 to 41.2/100 000, reaching about a half of the global average (78.6/100 000) but still almost twice as high as the average of high-income countries (24.3/100 000) by 2016; the reduction in mortality was higher among females than that among males (decreased 68.7% vs. 54.7%), and among adolescents aged 10-14 years than that among those aged 15-19 years (decreased 62.1% vs. 57.1%). During the 26-year period, the cause-specific mortality of all top 15 causes saw sharp decreases. Among them, communicable, maternal, and nutritional diseases saw the most significant decrease (78.1%), and its proportion in all adolescent deaths fell from 11.1% to 6.1%. Meanwhile, non-communicable diseases and injuries saw relatively small decreases (58.2% and 57.3% respectively), and their proportions rose from 33.4% and 55.6% to 34.8% and 59.1%, respectively. The top 5 causes of death changed from drowning (17.39/100 000 in mortality, 17.0% in proportion), road injuries (14.77/100 000, 14.4%), self-harm (11.44/100 000, 11.2%), leukemia (5.48/100 000, 5.4%) and interpersonal violence (3.12/100 000, 3.0%) in1990 into road injuries (9.27/100 000, 22.5%), drowning (6.83/100 000, 16.6%), leukemia(2.73/100 000, 6.6%), self-harm (2.53/100 000, 6.2%) and congenital birth defects (1.76/100 000, 4.3%) in 2016, and tuberculosis, poisonings and rheumatic heart disease had dropped out of the top 15 in 2016.@*Conclusion@#The mortality of Chinese adolescents aged 10-19 years has decreased significantly, but still higher than developed countries. Since 1990, injuries,especially for road injuries and drowning, have always been the leading causes of death among Chinese adolescents aged 10-19 years, followed by non-communicable diseases.

Analysis on the current situation of insufficient sleep and its association with physical exercise among Chinese Han students aged 9-18 years, in 2014 / 中华流行病学杂志

Objective To describe the situation of insufficient sleep and the association between insufficient sleep and physical exercise,among Chinese Han students aged 9-18 years.Methods We selected 172 197 Chinese Han students aged 9-18 years from the project 2014 Chinese National Survey on Students Constitution and Health.The average sleep duration per day of less than 9 h for children aged 9-12 years and of less than 8 h for adolescents aged 13-18 years,were defined as insufficient sleep.We described the distribution of sleep duration and the prevalence rates of insufficient sleep for each subgroup.Logistic regression models were established to assess the association between insufficient sleep and physical exercise.Results In 2014,6.6％,30.8％,26.3％,20.8％,13.8％ and 1.8％ of the Chinese Han students self-reported sleep duration were ＜6,6-,7-,8-and ≥ 10 h,respectively.The overall prevalence rate of insufficient sleep was 77.2％,with 75.8％ for boys and 78.6％ for girls.No gender disparity was found at each 9-11 age groups.However,in the 12-18 age groups,the prevalence rates for girls were significantly higher than that for boys.The prevalence rates of insufficient sleep for primary school,middle school and high school students were 66.6％,74.1％ and 93.8％,respectively.Rates were increasing with age for children aged 9-12 years and adolescents aged 13-18 years respectively.The three provinces with the lowest prevalence rates of insufficient sleep were Zhejiang (68.8％),Jiangsu (66.7％) and Shaanxi (65.2％).Data from the logistic regression models revealed that,when comparing to those students with only exercise of ＜0.5 h per day,the exercise hours of 0.5-1 h (OR=0.72,95％ CI:0.69-0.74) or ≥1 h (OR=0.46,95％ CI:0.44-0.47) per day seemed as protective factors for insufficient sleep.When compared with physicalexercise frequency ＜2 times per week,the 2 times (OR=0.82,95％CI:0.78-0.86) or ＞2 times (OR=0.65,95％CI:0.62-0.68) frequencies also appeared as protective.Conclusions The prevalence rate of insufficient sleep prevailing among students aged 9-18 years was high,in China.Our data called for setting up effective measures to deal with this situation.

Analysis on the current situation of insufficient sleep and its association with physical exercise among Chinese Han students aged 9-18 years, in 2014 / 中华流行病学杂志

Objective To describe the situation of insufficient sleep and the association between insufficient sleep and physical exercise,among Chinese Han students aged 9-18 years.Methods We selected 172 197 Chinese Han students aged 9-18 years from the project 2014 Chinese National Survey on Students Constitution and Health.The average sleep duration per day of less than 9 h for children aged 9-12 years and of less than 8 h for adolescents aged 13-18 years,were defined as insufficient sleep.We described the distribution of sleep duration and the prevalence rates of insufficient sleep for each subgroup.Logistic regression models were established to assess the association between insufficient sleep and physical exercise.Results In 2014,6.6％,30.8％,26.3％,20.8％,13.8％ and 1.8％ of the Chinese Han students self-reported sleep duration were ＜6,6-,7-,8-and ≥ 10 h,respectively.The overall prevalence rate of insufficient sleep was 77.2％,with 75.8％ for boys and 78.6％ for girls.No gender disparity was found at each 9-11 age groups.However,in the 12-18 age groups,the prevalence rates for girls were significantly higher than that for boys.The prevalence rates of insufficient sleep for primary school,middle school and high school students were 66.6％,74.1％ and 93.8％,respectively.Rates were increasing with age for children aged 9-12 years and adolescents aged 13-18 years respectively.The three provinces with the lowest prevalence rates of insufficient sleep were Zhejiang (68.8％),Jiangsu (66.7％) and Shaanxi (65.2％).Data from the logistic regression models revealed that,when comparing to those students with only exercise of ＜0.5 h per day,the exercise hours of 0.5-1 h (OR=0.72,95％ CI:0.69-0.74) or ≥1 h (OR=0.46,95％ CI:0.44-0.47) per day seemed as protective factors for insufficient sleep.When compared with physicalexercise frequency ＜2 times per week,the 2 times (OR=0.82,95％CI:0.78-0.86) or ＞2 times (OR=0.65,95％CI:0.62-0.68) frequencies also appeared as protective.Conclusions The prevalence rate of insufficient sleep prevailing among students aged 9-18 years was high,in China.Our data called for setting up effective measures to deal with this situation.

The Effect of Age, Walking Speed and the Morphological Growth of Lower Limbs on 4～6-year-old Children's Gait / 中国运动医学杂志

Objective To explore the effect of age,walking speed and the morphological growth of lower limbs on 4～6 years old children's gait,so as to provide theoretical references for children's gait assessment and the design of a walker robot.Methods Totally one hundred and fifty-seven children ranging in age from 4 to 6 were selected as subjects in this research.Gait parameters were acquired by the 3D shooting technique,while the morphological indexes of the lower extremity,including the length A of the lower extremity,calf length,thigh circumference,pelvic width,width between two greater trochanters,foot length,foot girth and foot width,were measured.The differences of gait parameters among children of different ages and sexes were compared using the variance analysis.The step regression analysis was carried out to study the relationship between the walking speed and other gait parameters.The relationship between children's gait and morphology was analyzed using the canonical correlation analysis.Results The six-year-old children's gait cycle,step length and walking speed were significantly higher than those of four-and five-year-old children(P＜0.05).The swing phase percentage of six-year-old children was significantly higher than that of four-year-old ones(P＜0.05).The support percentage of six-year-old children was significantly lower than that of the four-year-old(P＜0.05).With the increase of the walking speed,young children's step length,cadence and percentage of the swing phase increased linearly.And the gait cycle,percentage of double support phase and percentage of the support phase decreased linearly with the increase of the walking speed.There was significant correlation between the lower extremity length A,calf length,width between two greater trochanters and step length for the children aged from four to six.Conclusion For children aged 4 to 6 years,the step length,walking speed and gait cycle increase continuously with the increment of age,whereas the cadence and percentage of the support phase decrease with the increment of age.The step speed is significantly correlated with other gait parameters such as the step length,cadence and gait cycle.The length of lower extremities,calf length and width between two greater trochanters are the main factors which affect the step length.

A cross-sectional study of seroepidemiology of viral hepatitis among Uighurs in Shufu of Xinjiang / 中华预防医学杂志

Objective@#To explore the status of seroepidemiology on hepatitis A, B and C among students and residents aged equal or greater than 18 years in south Xinjiang, and to provide scientific evidence for prevention and control of viral hepatitis.@*Methods@#Uyghur students in four towns and villages were selected by cluster random sampling from Feb to May, 2015, and Uyghur residents aged 18 to 69 years were selected by stratified cluster sampling from May to September, 2016. 4 507 middle and primary Uygur students and 4 833 Uyghur resides equal or greater than 18 years attended this survey. Self-designed questionnaire was used to collect the demographic information. And Elisa test was adopted to detect HAV-IgG, HBsAg, HBsAb and HCV-IgG. Chi-square test was used to calculate the difference on antibody positive rate of three types of hepatitis among the participants.@*Results@#The overall HAV-IgG positive rate was 99.45% (9 289/9 340). The positive rates were 99.70% (4 006/4 018) in male and 99.27% (5 283/5 322) in female (χ2=7.95, P=0.005). The HAV-IgG positive rate among people aged 10 to 14 years was the highest (99.91%, 2 233/2 235), and the difference between the age specific HAV-IgG positive rates was statistical significant (χ2=38.21, P<0.001). The overall HBsAg positive rate was 4.11% (384 cases), with 4.55% (183 cases) for male and 3.78% (201 cases) for female. The HBsAg positive rate among participants 19 to 24 years old was the highest (9.46%, 21/222) and the differences between the age specific HBsAg was statistically significant (χ2=116.22, P<0.001). The HBsAb positive rate was 35.03% (3 272 cases), with 35.59% (1 430 cases) for male and 34.61% (1 842 cases) for female, and the HBsAb positive rate among participants aged 15 to 18 years was the highest, which was 69.12% (696/1 007). The differences between the age specific HBsAb rates appeared statistically significant (χ2=671.80, P<0.001). The overall HCV-IgG positive rate was 0.65%(61 cases). The HCV-IgG positive rate in female was 0.86% (46 cases) and 0.37% (15 cases) in male (χ2=8.51, P=0.004).The HCV-IgG positive rate among participants aged over 70 years was the highest (3.78%,9/238) , and the difference between the age specific HCV-IgG positive rates had statistic significance (χ2=70.30, P<0.001). The HAV-IgG positive rate in hepatitis A vaccinees (100%, 876/876) was higher than that among the non-vaccinees (99.40%, 8 413/8 464) (χ2=4.26, P=0.039). The HBsAb positive rate in hepatitis B vaccinees was 39.32% (1 816/4 619) which was higher than that among the non-vaccinees (30.84%, 1 456/4 721) (χ2=73.68, P<0.001).@*Conclusion@#The positive rate of overall HAV-IgG was high, male and participants aged between 10 to 14 had higher probability to be infected. But the infection rates of hepatitis B and C were low, with the low vaccination rate and the poor protective effectiveness of hepatitis B.

Modeling and simulation of transmission dynamics of syphilis in Bayinguoleng Mongolia Autonomous Prefecture of Xinjiang / 中华地方病学杂志

Objective By analyzing the data of new syphilis cases from 2008 to 2014 in Bayinguoleng Mongolia Autonomous Prefecture (Bazhou for short) of Xinjiang to further provide reference basis for setting up control strategies.Methods Using the new syphilis data reported in Bazhou of Xinjiang,we constructed a dynamic model of transmission dynamics of syphilis,and the model was simulated and quantitatively analyzed.Results The syphilis dynamical model was introduced,the methods of setting the relevant parameters were given.It was found that the established model fitted well (MA PE =1.59％,RMSPE =0.68％),and the basic reproduction number of outbreak epidemic was estimated to be R0 =1.06 (95％ CI:1.01-1.15),it was predicted that the cumulative incidence of syphilis in Bazhou was 18 145 cases by 2024.In 2023,the cumulative number of cases was 16 465,and the number of new cases reached 1 680 in 2024.The infection rate,the number of core group partners and the treatment rate were main factors influencing the prevalence of syphilis after comparison of the sensitivity of the model parameters.Conclusion There is still an upward trend in the prevalence of syphilis infection in Bazhou of Xinjiang,and relevant departments should strengthen the prevention and control measures in high-risk groups,promote the use of condoms and other comprehensive intervention measures to control the prevalence of syphilis.

Knowledge, attitude and practice to chronic diseases and associated influencing factors in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region / 中华流行病学杂志

Objective To investigate the knowledge,attitude and practice (KAP) to chronic diseases and associated influencing factors in Uygur adults in Kashgar of southern Xinjiang,and provide basic information for developing ethnic specific prevention and control strategies for chronic diseases.Methods With stratified cluster random sampling,investigations,including questionnaire survey,physical examination and laboratory tests were performed among local residents who were aged ≥ 18 years and selected in Shufu county in southern Xinjiang.KAP scores were calculated and unconditional logistic regression models were used to analyze influencing factors.Results A total of 4 772 Uygur adults were surveyed.The awareness rate of chronic disease related knowledge ranged from 4.32％ to 56.04％,while the awareness rate of preventive measures were from 1.76％ to 85.18％ and the participation rate of prevention program varied from 4.00％ to 97.99％.The average KAP score was 15.90 ± 4.20 and the rate of total KAP was 47.86％.Multi-factor analysis suggested the pass rate of total KAP score increased with educational level.Other factors positively associated with ‘KAP score pass rate’ were commercial insurance investment,hypertension,family history of common chronic diseases,female and abdominal obesity,while overweight was negatively associated with the KAP score pass rate.Conclusions The KAP level on chronic diseases was low in Uygur adults in Kashgar.It is necessary to continuously implement ethnic targeted health education and health promotion campaigns,especially in low education level,low income level,overweight and male groups.

Prevalence of hypertension and risk factors in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region / 中华流行病学杂志

Objective To investigate the prevalence of hypertension and risk factors in Uygur adults in Kashgar of Xinjiang.Methods A total of 4 748 Uygur adults aged ≥ 18 years selected through cluster random sampling in Shufu county of Kashgar prefecture were surveyed by means of questionnaire survey,physical examination and laboratory test.The prevalence,awareness,treatment and control rate of hypertension of different groups were calculated and risk factors of hypertension was analyzed by using non-conditional logistic regression model.Results The overall prevalence of hypertension was 15.73％ (age-adjusted prevalence was 13.75％).The prevalence rates of hypertension in men and women were 16.36％ (age-adjusted prevalence was 12.96％),15.39％ (age-adjusted prevalence was 14.34％),respectively.The rates of awareness,treatment and control of hypertension were 59.57％,52.74％,21.29％,respectively.The prevalence of hypertension increased with age.Compared with age group 18-34 years,the age groups 55-64,≥65 years had higher risk of hypertension and the OR values were 10.53,20.96 for men and 16.27,33.20 for women.The overweight (OR=1.47 for men,OR =1.82 for women,P＜0.05) and obesity (OR =1.88 for men,OR=2.66 for women,P＜0.05) also increased the risk of hypertension.The groups with family history of hypertension (OR=3.85 for men,OR=2.34 for women,P＜0.05) also had higher risk of hypertension.Hypertriglyceridemia was positively correlated with the prevalence of hypertension in men (OR=1.62,95％CI:1.09-2.41).Conclusions The prevalence of hypertension in Uygur adults in Kashgar area of Xinjiang was at relatively low level.The related risk factors were age,overweight,obesity,family history and hypertriglyceridemia in men and the risk factors were similar in women except hypertriglyceridemia.

Knowledge, attitude and practice to chronic diseases and associated influencing factors in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region / 中华流行病学杂志

Objective To investigate the knowledge,attitude and practice (KAP) to chronic diseases and associated influencing factors in Uygur adults in Kashgar of southern Xinjiang,and provide basic information for developing ethnic specific prevention and control strategies for chronic diseases.Methods With stratified cluster random sampling,investigations,including questionnaire survey,physical examination and laboratory tests were performed among local residents who were aged ≥ 18 years and selected in Shufu county in southern Xinjiang.KAP scores were calculated and unconditional logistic regression models were used to analyze influencing factors.Results A total of 4 772 Uygur adults were surveyed.The awareness rate of chronic disease related knowledge ranged from 4.32％ to 56.04％,while the awareness rate of preventive measures were from 1.76％ to 85.18％ and the participation rate of prevention program varied from 4.00％ to 97.99％.The average KAP score was 15.90 ± 4.20 and the rate of total KAP was 47.86％.Multi-factor analysis suggested the pass rate of total KAP score increased with educational level.Other factors positively associated with ‘KAP score pass rate’ were commercial insurance investment,hypertension,family history of common chronic diseases,female and abdominal obesity,while overweight was negatively associated with the KAP score pass rate.Conclusions The KAP level on chronic diseases was low in Uygur adults in Kashgar.It is necessary to continuously implement ethnic targeted health education and health promotion campaigns,especially in low education level,low income level,overweight and male groups.

Prevalence of hypertension and risk factors in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region / 中华流行病学杂志

Objective To investigate the prevalence of hypertension and risk factors in Uygur adults in Kashgar of Xinjiang.Methods A total of 4 748 Uygur adults aged ≥ 18 years selected through cluster random sampling in Shufu county of Kashgar prefecture were surveyed by means of questionnaire survey,physical examination and laboratory test.The prevalence,awareness,treatment and control rate of hypertension of different groups were calculated and risk factors of hypertension was analyzed by using non-conditional logistic regression model.Results The overall prevalence of hypertension was 15.73％ (age-adjusted prevalence was 13.75％).The prevalence rates of hypertension in men and women were 16.36％ (age-adjusted prevalence was 12.96％),15.39％ (age-adjusted prevalence was 14.34％),respectively.The rates of awareness,treatment and control of hypertension were 59.57％,52.74％,21.29％,respectively.The prevalence of hypertension increased with age.Compared with age group 18-34 years,the age groups 55-64,≥65 years had higher risk of hypertension and the OR values were 10.53,20.96 for men and 16.27,33.20 for women.The overweight (OR=1.47 for men,OR =1.82 for women,P＜0.05) and obesity (OR =1.88 for men,OR=2.66 for women,P＜0.05) also increased the risk of hypertension.The groups with family history of hypertension (OR=3.85 for men,OR=2.34 for women,P＜0.05) also had higher risk of hypertension.Hypertriglyceridemia was positively correlated with the prevalence of hypertension in men (OR=1.62,95％CI:1.09-2.41).Conclusions The prevalence of hypertension in Uygur adults in Kashgar area of Xinjiang was at relatively low level.The related risk factors were age,overweight,obesity,family history and hypertriglyceridemia in men and the risk factors were similar in women except hypertriglyceridemia.

Analysis of clinical competence test results of general practitioners in Shanghai Pudong New Area / 中华全科医师杂志

Objective To analyze the clinical competency test results of general practitioners (GPs) in Shanghai Pudong New Area.Methods Total 1 160 GPs from Pudong New Area attended the clinical ability tests,all participated in theory test and 327 GPs attended practice skill tests.The results were reviewed by computer and the scores were automatically generated.Results The average score and pass rate of theory test were (64.24 ± 12.23) points and 64.2％ (745/1 155),respectively.The average scores of GPs with master or above degree were the highest (67.09 ± 13.38 points),however,the pass rate of GPs with undergradnate degree was the highest (69.7％,349/501).GPs with senior professional title got the highest average score and pass rate [68.26 ± 9.92 points and 82.7％ (43/52),respectively].Introduction to General Practice (69.7％),Internal Medicine (68.6％) and Cancer (66.9％) were the top 3 subjects with the highest correct rate.The pass rate of clinical skills was 39.1％ (128/327),GPs with master degree or above (192.87) and those with junior professional titles (171.08) had the highest scores.GPs with master degree or above (50.0％,8/16) and those with intermediate professional title (40.1％,97/242)had the highest pass rate.Conclusions The analysis shows that the average score and pass rate of both theory test and clinic practice skills test are not satisfactory among GPs in Shanghai Pudong New Area.The clinical ability of GPs need to be further improved,and the study of some specific disciplines need to be further strengthened.

Correlation between caregivers′burden and the coping style among parents of cancer children / 现代临床护理

Objective To investigate the level of caregivers′burden and the coping style among parents of cancer children. Methods Totally, 229 parents of cancer children participated in the investigation by Chinese version of zarit burden interview (ZBI), Chinese version of coping health inventory for parents (CHIP) and self-designed general information questionnaire. The associations between caregivers′burden and coping styles were tested by Spearman correlation analysis. Results The caregiver′s burden on the parents was in the middle level with a total score of (30.50 ± 12.24). The coping style the parents took most frequently was to unite the family and keep a positive attitude and regard it as most effective. The caregiver′s burden was negatively associated with the positive coping style . Conclusion The parents of cancerous children suffer from middle level of burden . Nurses should assess the caregiver′s burden, provide targeted interventions to relieve it, help the to establish effective coping style and change their psychological and mental state and ultimately improve their quality of life.

Research on psychological resilience and its influencing factors among parents of children with cancer / 中国实用护理杂志

Objective To probe into the psychological resilience and its influencing factor among parents of children with cancer.Methods A total of 125 parents were investigated by self-designed general information questionnaire,Connor-Davidson psychological resilience scale (CD-RISC),Chinese version of Parents' Perception Uncertainty in Illness Scale (PPUS),Social Support Rating Scale (SSRS),self-rating depression scale (SDS) and self-rating anxiety scale (SAS).Results The total score of psychological resilience was (54.86±12.88) and the illness uncertainty score was (91.52±14.66).The social support score was moderate with a total score of (39.86±7.99).The anxiety and depression among parents got a total score of (40.08±7.19) and (44.61±7.38) respectively.Psychological resilience was negatively correlated with illness uncertainty and depression,and was positively correlated with the social support.The depression,illness uncertainty,residence,children's age,clinical diagnosis entered into the multiple linear regression equation of psychological resilience,predicting 30.1％ of total variation in psychological resilience.Conclusions Social support,illness uncertainty and depression are the important factors which affect psychological resilience among parents of children with cancer.Nurses should assess the social support that parents receive,the level of depression and the disease feeling of the parents,and provide targeted interventions to relieve it,help to establish effective coping style and improve their psychological state.

Stereological observation without bias of the effects of exercises and loads on bone morphology in rats / 中国组织工程研究

BACKGROUND: Bone morphological stereological observation is limited due to the difficulty in human experimental bone access. Animal studies overcome the limitation of human experiments and can directly evaluate bone quality through bone stereological histomorphometric parameters.OBJECTIVE: To explore the mechanism of the impacts of exercise on long bone development in adolescents through exercise and load experiments in rats.DESIGN: A randomized controlled study by employing experimental animals as subjects.SETTING: Laboratory of Sports of Beijing University of Physical Education and the Key Laboratory of Orthopaedics of Xijing Hospital Affiliated to the Fourth Military Medical University of Chinese PLA.MATERIALS: The study was conducted in the Laboratory of Sports of Beijing University of Physical Education and the Key Laboratory of Orthopaedics of Xijing Hospital Affiliated to the Fourth Military Medical University of Chinese PLA. Totally 120 male 4-week old SD rats were randomly paired into 12 groups with 10 rats each based on their body mass.METHODS: Incremental exercises with the combination of suspension and loading mode of rats were used in the study. The undecalcified slices of the right tibia were observed after double-fluorescence-labeling by tetracycline (TC) and calcein for the analysis of bone histomorphometric parameters including bone mass, structure and metabolism, etc. During the period of growth under different exercise strength and different modes of mechanic load by stereological sampling without bias.static or dynamic parameters of bone trabecula among groups of different modes for mechanical load.RESULTS: The increase or decrease of multiple parameters including bone mass, bone quality, bone structure and bone metabolism in low-loading exercise group were more regular than that of high-loading exercise group and control group. In the suspension group, the bone mineral apposition significantly reduced, and the relative volume of bone trabecula significantly decreased with the significantly increased thickness, decreased numbers and significant of increased separation. The biochemical indicators of bone metabolism and the biomechanical capability of suspension group were significantly lower than that of low-loading exercise group but similar to that of control group. All parameters of loading group were similar to those of low-loading exercise group with the characters of active osteogenesis and osteo-absorption but mainly osteogenesis, and significantly enhanced abilities of anti-destruction and anti-deformity in bone.CONCLUSION: Exercises of different strengths can produce different impacts on long bone development in rats of growth period. The integrated effects of low-loading exercises in bone metabolism, bone mass, bone histomorphology and bone biomechanics are better than those of high-loading exercises. This phenomenon suggests that appropriate increment of gravity load during the exercise processin children and adolescents is good for the improvement of the capability of bone metabolism and bone mechanics, which further improve the bone quality during development.